Epigenetic of Drug Use

Epigenetics is the study of the human body’s genomes, what their purpose is, how they are genetically inherited, and influence through environmental (Nutrition, chemical, physical, Psychosocial) factors that can activate or deactivate a single genome. At the change of the century, the genetic mapping of the human strain of DNA was believed to lead to breakthroughs in scientific and human health science. It was thought that through the genetic mapping of man that disease could be contained or prevented and a full understanding of an array of physical and mental disorders could be explained. However, what was found was quite contrary to what was believed to be factorial about DNA. Human beings’ DNA was found to be fluid and placid, through genetic inheritance from both the mother and father, one receives a set of chromosomes to include potentially all of the genetic mutations was only half of how one’s DNA is structured. Scientifics found that within these chromosomes some 26000 genomes can be activated or deactivated depending upon environmental factors, such as child development of social interaction can lead to activation of various genomes. Trauma can lead to the activation of such genomes. Another example would be a mother that suffers from depression may have an active gene that is known to be associated with depression, this same gene would have been transferred to the child through hereditary. The mixture of genetic inheritance and social interaction with mother’s depression can lead to hitting activation of this genome in the child creating depression. These two factors (hereditary and environmental factors) combine to form an epigenetic change in one genome. Another example of this could be the epigenetic changes through trauma. A man that wakes up in the middle of the night to hear a small child crying at his door barely dressed and could not be beyond the age of three could experience an epigenetic change activating genes that are connected with anxiety from the experance of seeing the child in this state. In the same manner, our genes through an epigenetic change can be turned off. In a paper submitted by Ethan Anderson, Rachel D Penrod, Sara Barry, Brandon Hughes, Makoto Taniguchi, and Christopher Cowan entitled “It is a complex issue: emerging connections between epigenetic regulators in drug addition to the European Journal of Neuroscience a review of research data and testing of mice deduced that a person regular consumption of drugs can alter DNA at the epigenetic level. Their study concluded that behaviors associated with addiction are in connection with enzymes and histone/DNA modifications in the Nac that are instrumental in effecting addictions (Drugs and addiction: an introduction …). Epigenetics is theorized to be involved in people with addiction disorders and is noted through DNA Methylation and Histone modification. DNA Methylation occurs when methyl groups are placed upon the C5 position of a cytokine that develops into 5-methylcytosine. Overall this transformation results in the ability to affect tissue (Butz and Newman 2020). Histone modifications enable the activation of genes through the use of acetyl groups that are added to the lysines on the tail’s oscines which causes the positive charge to be lost reduces the nucleosome hon=ld on DNA. Regular recurrent use of illicit drugs leads to prolonging alteration of various genomes such as BDNF which has been noted to become an altar for prolonged periods following substance use. This has an overall effect on the short- and long-term memory of the brain. Individual drugs have been tested on humans and mice to reduce their potential genome change with interesting results. Humans that ingest Alcohol and Nicotine, result in alteration of the genome MAOA. In addition, MAOA was associated with alteration in individuals who absorbed Nicotine through smoking. All of each occurred through DNA Methylation (It is a complex issue: emerging conne…). By understanding the biological changes within the DNA structure of an individual we can better understand the process in which one develops addictive behavior and the transition to back to functional lifestyle within the confines of sobriety.

Published by stmd1980

Hi, and thank you for joining me on my new site. Here I want to take time to discuss different aspects of Mental Health that I have observed over the last 17 years. I wanted to use this blog as an opportunity to discuss research, personal experience, and though the comment section have you the reader share your personal experience with mental health either yours or in a support role for your loved ones. Here on this form I will be targeting topic such as personality disorders, Autism, addiction, and other such aspect that effect many of us throughout the course of our lives. It is my hope through sharing information we can learn from each other.

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